Institutes of the Christian Religion is John Calvin's seminal work on Protestant systematic theology. Highly influential in the Western world and still widely read by theological students today, it was published in Latin in 1536 and in his native French in 1541, with the definitive editions appearing in 1559 (Latin) and in 1560 (French).

The book was written as an introductory textbook on the Protestant faith for those with some learning already and covered a broad range of theological topics from the doctrines of church and sacraments to justification by faith alone and Christian liberty, and it vigorously attacked the teachings of those Calvin considered unorthodox, particularly Roman Catholicism to which Calvin says he had been "strongly devoted" before his conversion to Protestantism. The over-arching theme of the book – and Calvin's greatest theological legacy – is the idea of God's total sovereignty, particularly in salvation and election.

The Institutes are a primary reference for the system of doctrine adopted by the Reformed churches, usually called Calvinism.

Book Three of the Institutes, "which contains a full exposition of the Third Part of the Apostles’ Creed, treats of the mode of procuring the grace of Christ, the benefits which we derive and the effects which follow from it, or of the operations of the Holy Spirit in regard to our salvation." (Summary from Wikipedia & Book 3 Argument)